The Deubiquitinase USP47 Stabilizes MAPK by Counteracting the Function of the N-end Rule ligase POE/UBR4 in Drosophila.
RAS-induced MAPK signaling is a central driver of the cell proliferation apparatus.Disruption of this pathway is widely observed in cancer and other pathologies.Consequently, considerable effort has been devoted to understanding the mechanistic aspects of RAS-MAPK signal transmission and regulation.While much information has been garnered on the st